Population
Cultured human umbilical vein endothelial cells (HUVECs)
Comparison
Cyclical mechanical stretch with or without… vs Unstretched cells or cells without inhibitors
Design
Preclinical
Follow-up
2 to 24 hours
Authors
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Findings remain preclinical; leaves open whether JNK-mediated TNF-alpha drives stretch-related vascular remodeling in vivo.
Cyclical mechanical stretch augments TNF-alpha production and MMP-14 and -2 gene expression in HUVECs, mediated at least in part through the JNK pathway.
Wang et al. (2003) studied this question.
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