What question did this study set out to answer?

This research aims to determine the impact of persistent viral genomes on clinical outcomes in patients with dilated cardiomyopathy.

January 1, 2015IntervirologyOpen Access

Clinical Significance of Viral Genome Persistence in the Myocardium of Patients with Dilated Cardiomyopathy

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Why the study?

Does myocardial viral persistence impact the risk of death or heart transplantation in patients with dilated cardiomyopathy?

Key Points

This research aims to determine the impact of persistent viral genomes on clinical outcomes in patients with dilated cardiomyopathy.
Fifty-two patients with dilated cardiomyopathy were followed for a median of 3.8 years.
Patients underwent coronary angiography and endomyocardial biopsy; viral genomes were analyzed using real-time PCR.
Histological examinations were performed using histo- and immunohistochemistry.
Viral genomes were detected in the myocardium of 32 out of 42 patients followed.
Nine out of 42 patients achieved the predefined clinical endpoint.
No significant correlation was found between viral genome presence and clinical outcomes.

Structured PICO

Does myocardial viral persistence impact the risk of death or heart transplantation in patients with dilated cardiomyopathy?

Population

52 patients with dilated cardiomyopathy (DCM), clinically stable for at least 6 months before hospitalization, who underwent coronary angiography and endomyocardial biopsy.

Intervention

Presence of myocardial viral persistence (parvovirus B19, cytomegalovirus, Coxsackie B virus, hepatitis B, and hepatitis C) detected by real-time polymerase chain reaction on endomyocardial biopsy.

Comparator

Absence of myocardial viral persistence.

Outcome

Death or heart transplantation.hard clinical

The presence of viral genomes in the myocardium of patients with stable dilated cardiomyopathy does not appear to significantly impact long-term clinical outcomes such as death or heart transplantation.

Discussion

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Implication

Should not prompt changes in dilated cardiomyopathy management based on viral genome status; leaves open the need for larger prospective studies.

Cite This Study

Nowalany-Kozielska et al. (2015) studied this question.

synapsesocial.com/papers/6a75f72a4555d8f90b70779f https://doi.org/10.1159/000443375

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Implication

Should not prompt changes in dilated cardiomyopathy management based on viral genome status; leaves open the need for larger prospective studies.

Clinical Significance of Viral Genome Persistence in the Myocardium of Patients with Dilated Cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Clinical Significance of Viral Genome Persistence in the Myocardium of Patients with Dilated Cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider