Why the study?
Does high-dose corticosteroid therapy improve myocardial dysfunction and wall thickening in a patient with eosinophilic myocarditis?
Does high-dose corticosteroid therapy improve myocardial dysfunction and wall thickening in a patient with eosinophilic myocarditis?
High-dose corticosteroid therapy can lead to dramatic clinical and echocardiographic improvement in patients with acute severe heart failure due to eosinophilic myocarditis.
May support steroid responsiveness in eosinophilic myocarditis with acute HF; leaves open need for controlled trials.
We report a case of a 34-year-old male with acute severe heart failure associated with marked concentric left ventricular wall thickening and biopsy evidence of eosinophilic myocardial infiltrate. This appears to be an unusual description of this degree of concentric myocardial thickening in eosinophilic myocarditis coupled with Doppler tissue echocardiography. Following high-dose corticosteroid treatment, wall thickness, systolic and diastolic left ventricular function normalized and the patient experienced a dramatic clinical improvement.
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Adsett et al. (2003) studied this question.
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