Why the study?
Does angiotensin II blockade with an ACE inhibitor or ARB restore albumin reabsorption and megalin expression in the proximal tubules of early-stage diabetic rats?
Population
Male Sprague-Dawley rats weighing 200-240 g with streptozotocin-induced diabetes, age-matched non-diabetic…
Comparison
Quinapril or candesartan for 2 weeks. vs Untreated diabetic rats and non-diabetic control…
Design
Preclinical, Diabetic rats were randomly divided into three groups matched for…
Follow-up
2 weeks of treatment
Authors
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ACEI/ARB restore tubular albumin endocytosis in diabetic rat models; hypothesis-generating and should not yet inform human practice.
Does angiotensin II blockade with an ACE inhibitor or ARB restore albumin reabsorption and megalin expression in the proximal tubules of early-stage diabetic rats?
Angiotensin II blockade with ACE inhibitors or ARBs restores proximal tubular albumin reabsorption by normalizing megalin expression in early-stage diabetic rats, providing a mechanism for their anti-proteinuric effects.
Tojo et al. (2003) studied this question.
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