Why the study?
Is urinary myoglobin measurement valuable for the diagnosis of myocardial infarction in patients admitted to a coronary care unit?
Is urinary myoglobin measurement valuable for the diagnosis of myocardial infarction in patients admitted to a coronary care unit?
Measurement of urinary myoglobin is of little value for diagnosing myocardial infarction, as it frequently occurs in non-MI patients as well.
Answers are grounded in this paper and cite their sources.
Does not support urinary myoglobin for MI diagnosis in CCU patients; leaves open validation of alternative biomarkers in prospective cohorts.
Serial determinations of urinary myoglobulin, β2-microglobulin and albumin, and of serum myoglobin, were performed in twenty-eight consecutive patients admitted to a coronary care unit. Patients with myocardial infarction (MI patients) all had higher serum levels of myoglobin then those with other diagnoses (OBS patients). Myoglobinuria occurred in 80% of MI patients and in half of the OBS patients. The appearance of myoglobin in urine was mainly accounted for by an impaired renal reabsorption of low molecular weight proteins. Measurement of urinary myoglobulin, in contrast to serum myoglobulin, is of little value for the diagnosis of myocardial infarction.
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Karlsson et al. (1978) studied this question.
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