Key result
Serial myoglobin assays detect AMI with 93% sensitivity in ED patients.
Why the study?
The sensitivity and specificity of a new myoglobin assay for acute myocardial infarction, considering total serum myoglobin and its percentage change over 2 hours, were not established.
Does serial myoglobin testing accurately detect acute myocardial infarction in admitted chest pain patients?
Observational (n=42)
Double-blind
No
Does serial myoglobin testing accurately detect acute myocardial infarction in admitted chest pain patients?
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Serial myoglobin testing over 2 hours provides high sensitivity for early detection of acute myocardial infarction in ED patients with chest pain.
Davis et al. (1996) conducted an observational in Possible acute myocardial infarction (n=42). Serial myoglobin assays vs. Clinical diagnosis (criterion standard) was evaluated on Sensitivity for detection of acute myocardial infarction (95% CI 66-100). Serial myoglobin assays over 2 hours demonstrated a sensitivity of 93% (95% CI: 66-100%) and specificity of 79% (95% CI: 59-92%) for detecting acute myocardial infarction in ED patients.
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