Key result
S-myoglobin quantitation had significantly higher sensitivity than S-creatine kinase for detecting acute myocardial infarction on admission, but lower specificity.
Why the study?
Does serum myoglobin quantitation provide better diagnostic value than creatine kinase for early detection of acute myocardial infarction?
Population
307 patients with suspected acute myocardial infarction and a reference group of healthy blood donors and…
Comparison
Serum myoglobin quantitation vs Serum creatine kinase (CK) quantitation
Design
Cohort
Follow-up
Up to 3 days (admission and following three mornings)
Authors
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Should not yet change early AMI diagnostic practice despite higher sensitivity than CK; leaves open optimal marker combinations for prospective validation.
Observational (n=307)
Does serum myoglobin quantitation provide better diagnostic value than creatine kinase for early detection of acute myocardial infarction?
Serum myoglobin is more sensitive than creatine kinase for the very early detection of acute myocardial infarction but suffers from lower specificity.
Nørregaard-Hansen et al. (1980) conducted an observational in Suspected acute myocardial infarction (AMI) (n=307). S-myoglobin quantitation vs. S-creatine kinase (CK) quantitation was evaluated on Sensitivity and specificity for detection of AMI. S-myoglobin quantitation had significantly higher sensitivity than S-creatine kinase for detecting acute myocardial infarction on admission, but lower specificity.
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