Key result
Serum myoglobin determination yielded a diagnostic sensitivity of 0.98 at 4 hours after admission, significantly higher than creatine kinase and aspartate aminotransferase (p<0.001) for early AMI.
Why the study?
Does serum myoglobin determination improve the early diagnosis of acute myocardial infarction compared to CK and ASAT?
Population
305 consecutive patients with suspected acute myocardial infarction (AMI)
Comparison
Serum myoglobin determination vs Serum creatine kinase and serum aspartate…
Design
Cohort
Authors
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May support earlier AMI evaluation; leaves open prospective validation before practice change.
Observational (n=305)
Does serum myoglobin determination improve the early diagnosis of acute myocardial infarction compared to CK and ASAT?
p-value: p=<0.001
Serum myoglobin determination provides superior diagnostic sensitivity and predictive value compared to CK and ASAT for the early diagnosis of acute myocardial infarction.
Roxin et al. (1984) conducted an observational in suspected acute myocardial infarction (AMI) (n=305). Serum myoglobin determination vs. Serum creatine kinase (CK) and aspartate aminotransferase (ASAT) was evaluated on Diagnostic sensitivity at 4 hours after admission (p=<0.001). Serum myoglobin determination yielded a diagnostic sensitivity of 0.98 at 4 hours after admission, significantly higher than creatine kinase and aspartate aminotransferase (p<0.001) for early AMI.
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