Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 8, 1996Archives of Internal Medicine

The Efficacy of Intravenous Amiodarone for the Conversion of Chronic Atrial Fibrillation

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does intravenous amiodarone improve conversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation compared to oral quinidine?

Population

32 patients with chronic atrial fibrillation (CAF) of more than 3 weeks' duration

Comparison

Intravenous amiodarone for initial conversion… vs Oral digoxin/quinidine for initial conversion…

Design

RCT, randomized, unblinded

Follow-up

9 months

Authors

NKNicholas Z. KerinBoston University

Discussion

Loading...

Member takes

Implication

Amiodarone may be preferred over quinidine for long-term rhythm control in chronic AF; extends RCT evidence on maintenance and tolerability.

Structured PICO

Does intravenous amiodarone improve conversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation compared to oral quinidine?

P
Population
32 patients with chronic atrial fibrillation (CAF) of more than 3 weeks' duration
I
Intervention
Intravenous amiodarone for initial conversion, followed by oral amiodarone for maintenance
C
Comparator
Oral digoxin/quinidine (containing 300 mg of quinidine) for initial conversion, followed by quinidine extended-action tablet for maintenance
O
Outcome
Conversion of chronic atrial fibrillation to sinus rhythm at 24 hourssurrogate

Intravenous amiodarone is as effective as oral quinidine for acute conversion of chronic atrial fibrillation, while oral amiodarone offers superior long-term maintenance of sinus rhythm and better tolerability.

Cite This Study

Nicholas Z. Kerin (1996) studied this question.

synapsesocial.com/papers/6a7620951ce449dc42708fbbhttps://doi.org/10.1001/archinte.1996.00440010061008

Topics

Persistent AF managementAtrial fibrillationAnticoagulation in AF
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amiodarone in the Management of Refractory Atrial Fibrillation1987 · 81 citations
  2. 2A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient.1984 · 140 citations
  3. 3The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle1970 · 554 citations
  4. 4Effects of amiodarone on sinus node in man.1979 · 57 citations
  5. 5Pharmacodynamics of Intravenous Amiodarone in the Dog1984 · 32 citations