Key result
IV amiodarone is linked to ~55% sinus rhythm conversion within 48 hours in recent-onset AF.
Why the study?
Does intravenous amiodarone improve conversion to sinus rhythm in patients with recent-onset atrial fibrillation?
Population
20 unselected patients with recent-onset atrial fibrillation admitted to a general internal medicine…
Design
Cohort
Follow-up
1 month
Authors
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Should not yet change practice given modest conversion and phlebitis risk in this small cohort; leaves open need for randomized comparisons.
Observational (n=20)
No
Does intravenous amiodarone improve conversion to sinus rhythm in patients with recent-onset atrial fibrillation?
Intravenous amiodarone showed a modest acute conversion rate (55%) for recent-onset atrial fibrillation, with better efficacy suggested in patients with rapid ventricular response and good left ventricular function.
Kreiss et al. (1999) conducted an observational in Recent-onset atrial fibrillation (n=20). Intravenous amiodarone was evaluated on Conversion to sinus rhythm within 48 hours. Intravenous amiodarone resulted in a 55% conversion rate to sinus rhythm within 48 hours in patients with recent-onset atrial fibrillation, with a 25% incidence of thrombophlebitis.
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