Why the study?
Does intravenous amiodarone improve conversion to sinus rhythm and heart rate reduction compared to digoxin in patients with recent-onset atrial fibrillation and flutter?
Population
50 patients with recent-onset, persistent, atrial fibrillation and flutter with ventricular rates above 130…
Comparison
Amiodarone intravenously over 24 h. vs Digoxin infused in three divided doses, each…
Design
RCT, randomly assigned, open-label
Follow-up
24 h
Authors
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Favors IV amiodarone for rapid conversion in recent-onset AF; extends RCT evidence versus digoxin but safety may favor first-line digoxin.
Does intravenous amiodarone improve conversion to sinus rhythm and heart rate reduction compared to digoxin in patients with recent-onset atrial fibrillation and flutter?
Intravenous amiodarone is more effective than digoxin for rapid conversion of recent-onset atrial fibrillation and flutter, but digoxin appears safer and is suggested as first-line therapy.
Hou et al. (1995) studied this question.
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