Why the study?
Do synthetic peptides corresponding to VP7 and VP4 of bovine rotavirus provide passive protection against rotavirus infection in a murine model?
Population
Female mice immunized before and during pregnancy, and their suckling pups challenged at 7 days of age with…
Comparison
Synthetic peptides corresponding to VP7 and VP4… vs Bovine rotavirus (BRV) as immunogen
Design
Preclinical
Authors
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Hypothesis-generating for peptide-based rotavirus vaccines; leaves open translation to human trials.
Do synthetic peptides corresponding to VP7 and VP4 of bovine rotavirus provide passive protection against rotavirus infection in a murine model?
Synthetic peptides derived from rotavirus VP7 and VP4 coupled to VP6 particles can induce effective passive protection against rotavirus in a murine model.
Ijaz et al. (1991) studied this question.
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