Monoclonal antibodies directed against rotavirus surface proteins vp3 and vp7 passively protected suckling mice against virulent rotavirus challenge and virus-induced diarrhea.
Do monoclonal antibodies against rotavirus surface proteins vp3 and vp7 protect suckling mice against rotavirus-induced diarrhea?
Monoclonal antibodies against rotavirus vp3 and vp7 provide passive protection against rotavirus-induced diarrhea in suckling mice, highlighting vp3's potential for heterotypic vaccine development.
Monoclonal antibodies directed against two rotavirus surface proteins (vp3 and vp7) as well as a rotavirus inner capsid protein (vp6) were tested for their ability to protect suckling mice against virulent rotavirus challenge. Monoclonal antibodies to two distinct epitopes of vp7 of simian rotavirus strain RRV neutralized RRV in vitro and passively protected suckling mice against RRV challenge. A monoclonal antibody directed against vp3 of porcine rotavirus strain OSU neutralized three distinct serotypes in vitro (OSU, RRV, and UK) and passively protected suckling mice against OSU, RRV, and UK virus-induced diarrhea. The role of vp3 in eliciting protection against heterotypic rotavirus challenge should be considered when developing a vaccine with cloned rotavirus genes. Alternatively, immunization with a reassortant rotavirus containing vp3 and vp7 from two antigenically distinct rotavirus parents might protect against diarrhea induced by two or more rotavirus serotypes.
Offit et al. (Thu,) conducted a other in Rotavirus-induced diarrhea. Monoclonal antibodies to rotavirus surface proteins vp3 and vp7 was evaluated on Protection against virulent rotavirus challenge and virus-induced diarrhea. Monoclonal antibodies directed against rotavirus surface proteins vp3 and vp7 passively protected suckling mice against virulent rotavirus challenge and virus-induced diarrhea.
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