The creation of an aortocaval shunt in mice successfully induces a model of chronic volume overload leading to overt congestive heart failure and myocardial hypertrophy.
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Validates aortocaval shunt as a reproducible murine model of volume-overload HF; leaves open translation to clinical therapeutics.
Scheuermann‐Freestone et al. (2001) studied this question.
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