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September 15, 2007AJP Heart and Circulatory Physiology

Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction

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Population

Rats undergoing coronary artery ligation (chronic MI model) or sham surgery

Comparison

Coronary artery ligation (myocardial infarction) vs Sham surgery (control)

Design

Preclinical

Follow-up

18 weeks

Authors

JSJames S. SwaneyHPHemal H. PatelUYUtako Yokoyama

Discussion

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Overview

May link reduced AC activity to post-MI fibroblast dysfunction in rats; leaves open therapeutic relevance in human remodeling.

Structured PICO

P
Population
Rats undergoing coronary artery ligation (chronic MI model) or sham surgery
I
Intervention
Coronary artery ligation (myocardial infarction)
C
Comparator
Sham surgery (control)
O
Outcome
Adenylyl cyclase activity, AC5/6 expression, and collagen synthesis in cardiac fibroblasts isolated from noninfarcted myocardiumsurrogate

Chronic myocardial infarction in rats leads to reduced adenylyl cyclase expression and activity and increased collagen production in cardiac fibroblasts, contributing to cardiac remodeling.

Cite This Study

Swaney et al. (2007) studied this question.

synapsesocial.com/papers/6a76243cfd97cd3fd98c5d7fhttps://doi.org/10.1152/ajpheart.00739.2007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II type1 receptor regulation and differential trophic effects on rat cardiac myofibroblasts after acute myocardial infarction2001 · 25 citations
  2. 2Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy1999 · 177 citations
  3. 3Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling2005 · 171 citations
  4. 4Adenylyl Cyclase Increases Survival in Cardiomyopathy2002 · 142 citations
  5. 5Fibrosis and hypertensive heart disease2000 · 301 citations