Why the study?
Does salt loading and depletion affect oxidative stress differently in salt-sensitive versus salt-resistant hypertensive subjects?
Population
27 hypertensive subjects classified as salt sensitive (SS, n=14) or salt resistant (SR, n=13)
Comparison
Inpatient protocol of salt loading and salt… vs Salt resistant (SR) hypertensive subjects
Design
Cohort
Follow-up
Acute (inpatient protocol)
Authors
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May implicate oxidative stress in salt-sensitive hypertension; hypothesis-generating and requires interventional confirmation before practice change.
Does salt loading and depletion affect oxidative stress differently in salt-sensitive versus salt-resistant hypertensive subjects?
Salt loading acutely increases oxidative stress in salt-sensitive hypertensive patients, which is reversed by salt depletion, providing a potential mechanism for salt-related cardiovascular morbidity.
Laffer et al. (2006) studied this question.
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