Why the study?
Does dietary NaCl loading increase mean arterial pressure in salt-sensitive black subjects by increasing asymmetrical dimethylarginine and preventing compensatory vasodilatation?
Population
37 healthy, mostly normotensive black subjects (19 salt-sensitive and 18 salt-resistant)
Comparison
Dietary NaCl loading over a 7-day period vs Salt-resistant subjects undergoing the same…
Design
Cohort
Follow-up
7 days
Authors
Loading...
ADMA changes may mediate salt-induced resistance rises in black subjects; hypothesis-generating and should not yet change practice.
Does dietary NaCl loading increase mean arterial pressure in salt-sensitive black subjects by increasing asymmetrical dimethylarginine and preventing compensatory vasodilatation?
Salt sensitivity in black subjects appears to be driven by a failure of systemic vascular resistance to decrease during salt loading, which is mediated by increases in asymmetrical dimethylarginine.
Schmidlin et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: