Why the study?
Does allopurinol reduce myocardial oxidative stress and attenuate cardiac fibrosis and left ventricular diastolic dysfunction in angiotensin II-induced hypertensive mice?
Population
8-week-old male C57BL/6J mice with angiotensin II subcutaneously infused for 4 weeks to mimic cardiac…
Comparison
Allopurinol in daily doses vs Normal saline
Design
Preclinical
Follow-up
4 weeks
Authors
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May merit human trials in hypertensive diastolic dysfunction; leaves open antifibrotic effects independent of blood pressure lowering.
Does allopurinol reduce myocardial oxidative stress and attenuate cardiac fibrosis and left ventricular diastolic dysfunction in angiotensin II-induced hypertensive mice?
Allopurinol attenuates cardiac fibrosis and diastolic dysfunction in a mouse model of AngII-induced hypertension by reducing oxidative stress and modulating the TGF-β1/Smad pathway.
Jia et al. (2010) studied this question.
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