Population
L-type Ca2+ channels containing the alpha 1C subunit and N-type Ca2+ channels in PC12 cells
Comparison
Phenylalkylamine (-)D888 vs Wild-type alpha 1C channels and N-type channels
Design
Preclinical
Authors
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Maps phenylalkylamine receptor site on L-type channels; leaves open whether residues enable selective blocker design.
Identifies three critical amino acid residues in the IVS6 segment of L-type calcium channels that form a receptor site for high-affinity block by phenylalkylamines.
Hockerman et al. (1995) studied this question.
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