Population
Isolated short toe muscle fibres of the frog (Rana temporaria)
Comparison
- and-isomers of the phenylalkylamine derivative… vs Absence of the drug
Design
Preclinical
Authors
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May guide isomer-specific Ca antagonist development; leaves open translation to mammalian cardiac electrophysiology.
D888 acts as a potent antagonist by stabilizing the inactivated state of both the voltage sensor and the Ca2+ channel in frog skeletal muscle, with the (-)-isomer being more potent.
Erdmann et al. (1989) studied this question.
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