March 3, 1986FEBS LettersOpen Access

Purified calcium channels have three allosterically coupled drug receptors

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Population

Purified Ca2+ channels from guinea-pig skeletal muscle t-tubules

Design

Preclinical

Authors

JSJörg StriessnigElectrophysiology AGA. GöllGKV Spitzenverband KMKurt MoosburgerUniversität Innsbruck

Discussion

Member takes

Implication

Allosteric coupling among calcium channel sites is evident in purified preparations; leaves open relevance to intact systems or drug effects.

Structured PICO

Population

Purified Ca2+ channels from guinea-pig skeletal muscle t-tubules

Intervention

Calcium channel blockers including d-cis-diltiazem, (-)-desmethoxyverapamil, and (+)-PN 200-110

Outcome

Binding characteristics (Bmax, Kd) and allosteric interactions of drug receptors on purified Ca2+ channelssurrogate

This preclinical study demonstrates that purified calcium channels possess three distinct drug-receptor sites that are reciprocally allosterically coupled.

Cite This Study

Striessnig et al. (1986) studied this question.

synapsesocial.com/papers/6a7cc0b5ec6509d062ba6032 https://doi.org/10.1016/0014-5793(86)80327-1

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Implication

Allosteric coupling among calcium channel sites is evident in purified preparations; leaves open relevance to intact systems or drug effects.

Purified calcium channels have three allosterically coupled drug receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Purified calcium channels have three allosterically coupled drug receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider