January 13, 1987Biochemistry

Monoclonal antibodies that coimmunoprecipitate the 1,4-dihydropyridine and phenylalkylamine receptors and reveal the calcium channel structure

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Population

Rabbit transverse-tubule membranes, and membranes from rat, mouse, chicken, frog skeletal muscle, and rabbit…

Design

Preclinical

Authors

SVSylvie VandaeleUniversité de Montréal MFMichel FossetCentre National de la Recherche Scientifique JGJ P GalizziAVL (France)

Discussion

Member takes

Implication

Advances molecular mapping of calcium channel receptors; leaves open translation to selective human therapies.

Structured PICO

Population

Rabbit transverse-tubule membranes, and membranes from rat, mouse, chicken, frog skeletal muscle, and rabbit heart, brain, and intestinal smooth muscle

Intervention

Monoclonal antibodies against (+)-PN 200-110 and (-)-demethoxyverapamil binding components of the voltage-dependent calcium channel

Outcome

Structural characterization of the calcium channel via immunoprecipitationsurrogate

Basic science study demonstrating that 1,4-dihydropyridine and phenylalkylamine receptors reside on a single 170 kDa polypeptide chain of the voltage-dependent calcium channel.

Cite This Study

Vandaele et al. (1987) studied this question.

synapsesocial.com/papers/6a7198eae5469ee92be20d11 https://doi.org/10.1021/bi00375a002

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Monoclonal antibodies that coimmunoprecipitate the 1,4-dihydropyridine and phenylalkylamine receptors and reveal the calcium channel structure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Monoclonal antibodies that coimmunoprecipitate the 1,4-dihydropyridine and phenylalkylamine receptors and reveal the calcium channel structure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider