February 1, 1989Journal of Biological ChemistryOpen Access

Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies

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Population

Rabbit skeletal muscle (and other species including avian and amphibian)

Design

Preclinical

Authors

ASAlan H. SharpUniversity of North Carolina at Chapel Hill KCKevin P. CampbellHeart Failure & Transplant

Discussion

Member takes

Implication

Establishes gamma subunit as core DHP receptor component in skeletal muscle; extends channel characterization but leaves open human functional and therapeutic roles.

Structured PICO

Population

Rabbit skeletal muscle (and other species including avian and amphibian)

Intervention

Subunit-specific polyclonal antibodies against the gamma subunit (32,000-Da polypeptide) and other subunits

Outcome

Characterization of the association of the 32,000-Da polypeptide (gamma subunit) with other subunits of the dihydropyridine receptor

The 32,000-Da polypeptide (gamma subunit) is demonstrated to be an integral and distinct component of the 1,4-dihydropyridine receptor in skeletal muscle.

Cite This Study

Sharp et al. (1989) studied this question.

synapsesocial.com/papers/6a7198eae5469ee92be20d0a https://doi.org/10.1016/s0021-9258(19)81686-1

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Implication

Establishes gamma subunit as core DHP receptor component in skeletal muscle; extends channel characterization but leaves open human functional and therapeutic roles.

Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider