Key result
The purified cardiac Ca2+ channel consists of a major 170-kDa component comprising a 140-kDa peptide linked by disulfide bonds to smaller 32-29 kDa peptides, highly homologous to skeletal muscle.
The dihydropyridine-sensitive calcium channel in cardiac tissue has a subunit structure highly homologous to that of skeletal muscle, consisting of a 170 kDa complex.
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Characterizes cardiac L-type Ca2+ channel subunits; leaves open implications for isoform-selective pharmacotherapy.
Cooper et al. (1987) studied this question. Purification of dihydropyridine-sensitive voltage-dependent Ca2+ channel was evaluated on Characterization of the purified cardiac Ca2+ channel. The purified cardiac Ca2+ channel consists of a major 170-kDa component comprising a 140-kDa peptide linked by disulfide bonds to smaller 32-29 kDa peptides, highly homologous to skeletal muscle.
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