Key result
Adding db-cAMP or forskolin to transformed CHO cells induced phosphorylation of the 250-kDa alpha 1 subunit protein and stimulated the DHP-sensitive Ba current.
The cardiac DHP-sensitive Ca channel is regulated by cAMP-dependent phosphorylation of the alpha 1 subunit.
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Does not support clinical changes in Ca channel management; leaves open in vivo confirmation in native cardiomyocytes.
Yoshida et al. (1992) studied this question. db-cAMP or forskolin was evaluated on Phosphorylation of the 250-kDa protein and stimulation of DHP-sensitive Ba current. Adding db-cAMP or forskolin to transformed CHO cells induced phosphorylation of the 250-kDa alpha 1 subunit protein and stimulated the DHP-sensitive Ba current.
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