August 1, 2000British Journal of PharmacologyOpen Access

Effects of BDF 9198 on action potentials and ionic currents from guinea‐pig isolated ventricular myocytes

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Population

Guinea-pig isolated ventricular myocytes and ventricular muscle strips from male guinea-pigs (~400 g)

Comparison

BDF 9198 vs Control conditions

Design

Preclinical

Authors

KYKathryn H. YuillUniversity of the West of England MCMary K. ConveryQueen's University Belfast PDPhilip C. DooleyLa Trobe University

Discussion

Member takes

Implication

Warrants caution for proarrhythmic risk with persistent late sodium current inotropes; leaves open human translation from this animal model.

Structured PICO

Population

Guinea-pig isolated ventricular myocytes and ventricular muscle strips from male guinea-pigs (~400 g)

Intervention

BDF 9198 (concentrations ranging from 1x10^-10 M to 1x10^-5 M)

Comparator

Control conditions (normal Tyrode's solution without drug)

Outcome

Action potential duration at 50% repolarization (APD50) and sodium current (INa) modulationsurrogate

BDF 9198 acts as a positive inotrope but prolongs action potential duration by inducing a persistent late sodium current, suggesting proarrhythmic potential.

Cite This Study

Yuill et al. (2000) studied this question.

synapsesocial.com/papers/6a73c492f96a1419040dd28d https://doi.org/10.1038/sj.bjp.0703476

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Implication

Warrants caution for proarrhythmic risk with persistent late sodium current inotropes; leaves open human translation from this animal model.

Effects of BDF 9198 on action potentials and ionic currents from guinea‐pig isolated ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of BDF 9198 on action potentials and ionic currents from guinea‐pig isolated ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider