Why the study?
Does BDF 9198 improve force of contraction in human nonfailing and failing myocardium?
Population
Electrically driven left ventricular human papillary muscle strips from failing and nonfailing myocardium
Comparison
BDF 9198 (0.01-30 microM) vs BDF 9148, isoprenaline, and calcium
Design
Preclinical
Authors
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No clinical role in heart failure yet; leaves open translation of Na+-channel modulation from animal models to humans.
Does BDF 9198 improve force of contraction in human nonfailing and failing myocardium?
BDF 9198 is a potent positive inotropic agent in failing human myocardium, suggesting potential utility in heart failure where sensitivity to Na+-channel modulators is increased.
Müller‐Ehmsen et al. (1998) studied this question.
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