April 1, 1992Journal of Cardiovascular Pharmacology
Na+-Channel Activators Increase Cardiac Glycoside Sensitivity in Failing Human Myocardium
Key result
BDF 9148 enhances ouabain inotropy by ~2.9 mN but increases toxicity.
- P<0.01
- n=24
Why the study?
The interaction between the Na+-channel activator BDF 9148 and the cardiac glycoside ouabain in failing human myocardium and its effects on inotropy and toxicity were not well understood.
Population
19 failing (NYHA IV) and 5 nonfailing human myocardium samples
Comparison
Ouabain alone vs ouabain after prestimulation with BDF 9148
Design
Ex vivo study of electrically driven human papillary muscle strips
Authors
Discussion
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Implication
BDF may accelerate ouabain inotropy and toxicity in vitro; leaves open whether combined Na+-channel activator-glycoside use warrants clinical caution.
PICO
P
Population
24 human myocardium samples (19 from terminally failing NYHA IV heart transplants and 5 from nonfailing donors) studied in vitro.
I
Intervention / Comparator
BDF 9148 and ouabain vs Ouabain alone (OUA (0.01–0.1 μM), BDF (0.1 μM, 1 μM))
O
Primary Outcome
Isometric force of contraction (FOC), p=< 0.01
Main Result
p-value: p=< 0.01
Cite This Study
Schwinger et al. (1992) studied Heart failure (n=24). BDF 9148 and ouabain vs. Ouabain alone was evaluated on Isometric force of contraction (FOC) (p=< 0.01). Prestimulation with the Na+-channel activator BDF 9148 significantly enhanced the inotropic effect of ouabain on isometric force of contraction (+2.9±0.4 mN; p<0.01) but also increased toxicity.