Key result
In failing human myocardium, the Na+-channel activator (+/-)BDF 9148 and ouabain increased force of contraction as effectively as in nonfailing tissue, with higher potency for (+/-)BDF 9148 (P<0.05).
Why the study?
Does (+/-)BDF 9148 or ouabain improve force of contraction in failing human myocardium compared to nonfailing myocardium?
Population
Electrically driven left ventricular human papillary muscle strips and skinned fibre preparations from…
Comparison
BDF 9148 and ouabain vs Isoprenaline and Ca2+ as controls; nonfailing…
Design
Preclinical
Authors
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Hypothesis-generating for Na+-raising agents in HF; clinical translation requires prospective trials.
Does (+/-)BDF 9148 or ouabain improve force of contraction in failing human myocardium compared to nonfailing myocardium?
p-value: p=<0.05
Agents that increase intracellular Na+ (like BDF 9148 and ouabain) maintain their positive inotropic effectiveness in failing human myocardium, likely due to altered Na+ homeostasis.
Müller‐Ehmsen et al. (1997) studied Dilative cardiomyopathy, heart failure (n=28). (+/-)BDF 9148 and ouabain vs. Isoprenaline, Ca2+, and nonfailing myocardium was evaluated on Force of contraction (p=<0.05). In failing human myocardium, the Na+-channel activator (+/-)BDF 9148 and ouabain increased force of contraction as effectively as in nonfailing tissue, with higher potency for (+/-)BDF 9148 (P<0.05).
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