Why the study?
How do different inotropic interventions affect contraction and Ca2+ transients in isolated human nonfailing right auricular trabeculae?
How do different inotropic interventions affect contraction and Ca2+ transients in isolated human nonfailing right auricular trabeculae?
Different positive inotropic agents have distinct effects on force and intracellular calcium transients, suggesting some may be less advantageous in conditions with altered calcium homeostasis like heart failure.
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Highlights agent-specific Ca2+ effects in human myocardium; hypothesis-generating for inotrope selection in heart failure.
Brixius et al. (1997) studied this question.
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