October 1, 1990Circulation Research

Sarcolemma, sarcoplasmic reticulum, and sarcomeres as limiting factors in force production in rat heart.

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Population

Rat myocardium (thin ventricular trabeculae)

Comparison

Inotropic interventions including high [Ca2+]o… vs Control conditions

Design

Preclinical

Authors

VSVincent J. A. SchoutenMedtronic (Netherlands)JBJeroen J.J. BucxDiakonessenhuis hospital PTPieter P. de TombeHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Identifies distinct force-limiting sites in rat myocardium; hypothesis-generating for targeted inotropy but should not yet inform clinical practice.

Structured PICO

Population

Rat myocardium (thin ventricular trabeculae)

Intervention

Inotropic interventions including high [Ca2+]o, low [Na+]o, high [K+]o, tetraethylammonium chloride, postextrasystolic potentiation, Sr2+ (10 mM), ryanodine, and isoproterenol

Comparator

Control conditions (stimulation frequency 0.2 Hz; [Ca2+]o 1 mM; [K+]o 5 mM; [Na+]o 150 mM)

Outcome

Peak force of contraction, sarcomere length, and action potentialssurrogate

This study identifies the sarcolemma, sarcoplasmic reticulum, and sarcomeres as distinct limiting factors for force production in rat myocardium depending on the inotropic stimulus.

Cite This Study

Schouten et al. (1990) studied this question.

synapsesocial.com/papers/6a7ea11ceddee3b6110d1f9c https://doi.org/10.1161/01.res.67.4.913

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Implication

Identifies distinct force-limiting sites in rat myocardium; hypothesis-generating for targeted inotropy but should not yet inform clinical practice.