Why the study?
Does BAY K 8644 improve myocardial economy and efficiency compared to isoprenaline in mammalian failing and non-failing myocardium?
Population
Guinea pig right ventricular papillary muscles and isolated failing and non-failing working rat hearts
Comparison
BAY K 8644 (10^-5 M) vs Isoprenaline (10^-8 M)
Design
Preclinical
Authors
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May inform inotrope development targeting contraction economy; hypothesis-generating and should not yet change practice.
Does BAY K 8644 improve myocardial economy and efficiency compared to isoprenaline in mammalian failing and non-failing myocardium?
Inotropic stimulation with the calcium channel activator BAY K 8644 is associated with higher myocardial economy and efficiency compared to beta-adrenergic stimulation with isoprenaline in mammalian heart models.
Ruf et al. (1996) studied this question.
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