Population
Guinea pig and rat cardiac tissue (papillary muscle and isolated myocytes)
Comparison
BDF 9148 and DPI 201-106 vs Comparison between the two agents and between…
Design
Preclinical
Authors
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Animal findings on inotropic agents warrant no clinical adoption; leaves open species-specific translational mechanisms for future study.
BDF 9148 and DPI 201-106 exhibit species-dependent differences in their effects on action potential duration and contractility, likely due to differences in excitation-contraction coupling.
Hoey et al. (1994) studied this question.
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