October 1, 1986British Journal of PharmacologyOpen Access

Antiarrhythmic effects of DPI 201‐106

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Why the study?

Does DPI 201-106 demonstrate local anaesthetic and antiarrhythmic effects in preclinical models?

Population

Preclinical models including cat cervical vagus nerves in vitro, rats with coronary artery…

Design

Preclinical

Authors

GSGünter ScholtysikUniversity of Bern FWFrances M. K. WilliamsKing's College London

Discussion

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Implication

Animal data suggest selective antiarrhythmic activity; clinical translation and safety remain untested.

Structured PICO

Does DPI 201-106 demonstrate local anaesthetic and antiarrhythmic effects in preclinical models?

Population

Preclinical models including cat cervical vagus nerves in vitro, rats with coronary artery reperfusion-induced ventricular fibrillation or aconitine-induced arrhythmias, and guinea-pigs with ouabain-induced arrhythmias

Intervention

DPI 201-106 (in vitro concentration-dependent application; intravenous infusions of 0.3 mg kg-1 min-1 in rats; pretreatment in aconitine model)

Outcome

Local anaesthetic activity (compound action potential amplitude and conduction velocity) and antiarrhythmic activity (prevention of ventricular fibrillation, arrhythmogenic doses of aconitine, protection against ouabain-induced arrhythmias)surrogate

DPI 201-106 demonstrates local anaesthetic and potential antiarrhythmic effects in preclinical animal models.

Cite This Study

Scholtysik et al. (1986) studied this question.

synapsesocial.com/papers/6a88fde47e279b5a9518bb40 https://doi.org/10.1111/j.1476-5381.1986.tb10258.x

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Antiarrhythmic effects of DPI 201‐106

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antiarrhythmic effects of DPI 201‐106

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider