Mechanism of the Vasodilator Effects of the Cardiotonic Agent DPI 201-106

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Why the study?

Does the cardiotonic agent DPI 201-106 cause vasodilatation through calcium antagonism in animal models?

Population

Cats anaesthetized with chloralose/urethane (in vivo experiments) and rabbit aorta (in vitro experiments)

Design

Preclinical

Authors

Discussion

DPI calcium antagonism in rabbit aorta is hypothesis-generating; leaves open relevance to human cardiotonic therapy.

Does the cardiotonic agent DPI 201-106 cause vasodilatation through calcium antagonism in animal models?

Population

Cats anaesthetized with chloralose/urethane (in vivo experiments) and rabbit aorta (in vitro experiments)

Intervention

DPI 201-106 (DP) infused i.v. at doses between 0.3 and 3 mg/kg (in vivo) and applied for 15 min, 1, and 2 h pretreatment (in vitro)

Outcome

Blood pressure, peripheral vasodilatation, heart rate, coronary blood flow, depolarization-induced contraction, and 45Ca2+ uptakesurrogate

The vasodilator effects of the cardiotonic agent DPI 201-106 appear to be mediated by calcium antagonism.

Hof et al. (1985) studied this question.

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