Key result
DPI 201-106 administration significantly prolonged the corrected QT interval from 417 to 502 ms (P<0.05) and the ventricular effective refractory period.
Why the study?
What are the cardiac electrophysiologic effects of the positive inotropic agent DPI 201-106?
Population
16 patients undergoing cardiac electrophysiologic evaluation
Comparison
Intravenous DPI 201-106 vs Baseline (before DPI 201-106 administration)
Design
Cohort
Follow-up
During infusion (acute)
Authors
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QT prolongation with DPI 201-106 signals potential proarrhythmic risk requiring monitoring; leaves open net electrophysiologic effects in larger cohorts.
What are the cardiac electrophysiologic effects of the positive inotropic agent DPI 201-106?
Absolute Event Rate: 502% vs 417%
p-value: p=<0.05
DPI 201-106 exhibits differential electrophysiological effects on the atria and ventricles, notably prolonging the QT interval and ventricular effective refractory period while shortening atrial repolarization time and potentially provoking atrial fibrillation.
Butrous et al. (1988) studied this question. DPI 201-106 vs. Baseline (before administration) was evaluated on Corrected QT interval (p=<0.05). DPI 201-106 administration significantly prolonged the corrected QT interval from 417 to 502 ms (P<0.05) and the ventricular effective refractory period.
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