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August 1, 1991British Journal of PharmacologyOpen Access

Inotropic and electrophysiological effects of BDF 9148, a congener of DPI 201–106, in guinea‐pig atria and papillary muscles

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Authors

HBHelmut BraschUniversity of Lübeck HIH. IvenInstitute for Integrative and Experimental Genomics

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Implication

BDF 9148 increases contractility in guinea-pig atria and papillary muscle; leaves open any clinical role pending in vivo validation.

Key Points

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Cite This Study

Brasch et al. (1991) studied this question.

synapsesocial.com/papers/6a72dc33b0d581bd9f303e22 https://doi.org/10.1111/j.1476-5381.1991.tb12356.x

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clinical cardiac electrophysiologic evaluation of the positive inotropic agent, DPI 201–1061988 · 14 citations
2The effect of a new inotropic agent, DPI 201‐106, on systolic time intervals and the electrocardiogram in healthy subjects.1987 · 18 citations
3Haemodynamic effects of DPI 201–106, following single intravenous dose administration to patients with moderate cardiac failure1988 · 10 citations
4Subsensitivity of the Failing Human Heart to Isoprenaline and Milrinoneo is Related to β-Adrenoceptor Downregulation1988 · 97 citations
5Mechanisms of positive inotropic effects and delayed relaxation produced by DPI 201–106 in mammalian working myocardium: effects on intracellular calcium handling1989 · 26 citations