Population
Isolated cardiac preparations (left atria and papillary muscles) from rats, guinea pigs, and rabbits
Design
Preclinical
Authors
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Species differences in D 600 potency caution against human extrapolation; leaves open comparative calcium-handling studies across models.
Compound D 600 exhibits species-dependent negative inotropic potency, suggesting varying reliance on extracellular calcium for cardiac contraction among rats, guinea pigs, and rabbits.
Siegl et al. (1980) studied this question.
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