Electrical and Mechanical Responses to Diltiazem in Potassium Depolarized Myocardium of the Guinea Pig

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Population

Guinea pig papillary muscle and ventricular muscle fibers

Comparison

Diltiazem at lower (1.1 X 10 M) and higher (1.1… vs Control conditions (K-rich Tyrode's solution)

Design

Preclinical

Authors

Discussion

No immediate implications for patient care; leaves open mechanistic exploration of dose-dependent calcium effects in myocardium.

Population

Guinea pig papillary muscle and ventricular muscle fibers

Intervention

Diltiazem at lower (1.1 X 10(-7) M) and higher (1.1 X 10(-5) M) concentrations

Comparator

Control conditions (K-rich Tyrode's solution)

Outcome

Electrical properties (overshoot, maximum rate of rise [Vmax] of action potential) and mechanical activities (contractile force)surrogate

Diltiazem decreases myocardial contractile force in guinea pigs, likely by interfering with calcium influx or reducing intracellular free calcium.

Nakajima et al. (1976) studied this question.

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