Functional and autoradiographic characterization of dopamine D2-like receptors in the guinea pig heart

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Population

Guinea pig hearts (isolated preparations)

Design

Preclinical

Authors

Discussion

D3/D4 agonists may modulate guinea pig cardiac function; leaves open translation to human physiology or therapy.

Population

Guinea pig hearts (isolated preparations)

Intervention

Selective agonists of D3 and D4 receptors ((+/-)-7-OH-DPAT and PD 168 077, 10(-9) to 10(-5) M)

Outcome

Presence of D3 and D4 receptors and their chronotropic and inotropic effectssurrogate

D3 and D4 receptors are present in the guinea pig heart and their activation induces significant negative chronotropic and inotropic effects.

Need additional information with an antagonist and an agonist of improved potency and selectivity to understand the respective roles of D3 and D4 receptors in the cardiac functions

Gómez et al. (2002) studied this question.

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