Why the study?
Does D-600 and its optical isomers reduce force of contraction in cat papillary muscles and guinea-pig auricles?
Population
Cat papillary muscles and guinea-pig left auricles
Comparison
D-600 and its optical isomers (-D-600 and-D-600) vs Drug-free solution (washing)
Design
Preclinical
Follow-up
Up to 100 minutes
Authors
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Irreversible negative inotropy in isolated myocardium cautions against clinical extrapolation; leaves open binding mechanisms and in vivo relevance.
Does D-600 and its optical isomers reduce force of contraction in cat papillary muscles and guinea-pig auricles?
D-600 and its isomers exert potent, irreversible negative inotropic effects on myocardial tissue that do not correlate with total tissue concentration after full development.
Ludwig et al. (1977) studied this question.
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