Why the study?
Does verapamil alter myocardial contractility and the inotropic response to ouabain in perfused rabbit ventricular preparations?
Population
Perfused rabbit ventricular preparations
Comparison
Verapamil (0.2 µM to 1.0 µM) and ouabain (0.5 µM) vs Control
Design
Preclinical
Authors
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Verapamil's effects on contractility in rabbit hearts leave open distinct inotropic mechanisms; hypothesis-generating without clinical translation.
Does verapamil alter myocardial contractility and the inotropic response to ouabain in perfused rabbit ventricular preparations?
Verapamil decreases myocardial contractility and alters the frequency-force relationship but does not prevent the maximum positive inotropic response to ouabain, suggesting distinct mechanisms for frequency-induced and glycoside-induced inotropism.
McCans et al. (1974) studied this question.
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