Population
15-day-old chick embryos
Comparison
Pretreatment with 1 mumol of… vs Vehicle
Design
Preclinical
Follow-up
44 hours
Authors
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Hypothesis-generating for A1-receptor desensitization in avian hearts; leaves open relevance to mammalian or human myocardium.
Chronic exposure to R-PIA produces downregulation of A1-adenosine receptors and homologous desensitization of the negative inotropic response to adenosine in embryonic chicken hearts.
Shryock et al. (1989) studied this question.
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