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Demonstrates that changes in cerebral blood flow induce parallel shifts in cerebrospinal fluid pressure in humans, suggesting direct hemodynamic coupling.
WE HAVE previously reported that changes in cerebral blood flow may have a profound effect in the same direction on the cerebrospinal fluid pressure of rhesus monkeys.¹The present communication deals with this relationship in man. MATERIAL AND METHODS The types of patients studied and the methods of continuously recording the several pressures of interest have been described.²Included in this study are patients who were sufficiently cooperative to hyperventilate and lie quietly. OBSERVATIONS The administration of carbon dioxide in air increases the cerebral blood flow³and the cerebrospinal fluid pressure.⁴Hyperventilation decreases the flow⁵and the fluid pressure.⁴The cerebrospinal fluid pulse pressure varies concomitantly with the irregular arterial pulses of auricular fibrillation and extrasystoles. These procedures and conditions usually cause concomitant changes in the arterial pressure in the same direction, which have been assumed by other investigators to be the causative mechanism,
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Henry W. Ryder (1952) studied this question.
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