Key result
Experimental manipulations including hypoxia, hypercapnia, and epinephrine infusion were used to evaluate dynamic pressure-flow relationships of brain blood flow in monkeys.
Population
Rhesus monkey experimental model for brain vascular bed pressure-flow data
Design
Preclinical
Authors
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Primate pressure-flow data warrant no change in human cerebral autoregulation practice; leaves open clinical translation of vasomotor dynamics.
This preclinical model demonstrates that in the rhesus monkey brain vascular bed, changes in vasomotor tone cause a vertical shift in dynamic pressure-flow relationships, while resistance changes alter the slope.
Early et al. (1974) studied this question. Physiological condition changes (e.g., hypoxia, hypercapnia, epinephrine) was evaluated on Dynamic pressure-flow relationships of brain blood flow. Experimental manipulations including hypoxia, hypercapnia, and epinephrine infusion were used to evaluate dynamic pressure-flow relationships of brain blood flow in monkeys.
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