Dynamic pressure–flow relationship of the cerebral circulation during acute increase in arterial pressure
Why the study?
Does phenylephrine-induced acute cerebral vasoconstriction alter the dynamic pressure-flow relationship of the cerebral circulation in healthy subjects?
Population
13 healthy subjects, mean age 30 +/- 7 years
Comparison
Phenylephrine infusion at 0.5, 1.0 and 2.0… vs Baseline (pre-infusion)
Design
Other
Authors
Discussion
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Member takes
Implication
Acute vasoconstriction may alter cerebral autoregulation; hypothesis-generating and leaves clinical translation open.
Structured PICO
Does phenylephrine-induced acute cerebral vasoconstriction alter the dynamic pressure-flow relationship of the cerebral circulation in healthy subjects?
P
Population
13 healthy subjects, mean age 30 +/- 7 years
I
Intervention
Phenylephrine infusion at 0.5, 1.0 and 2.0 microg kg(-1) min(-1)
C
Comparator
Baseline (pre-infusion)
O
Outcome
Transfer function between spontaneous changes in blood pressure (BP) and cerebral blood flow velocity (CBFV)surrogate
Acute increases in arterial pressure and cerebral vasoconstriction modulate the dynamic pressure-flow relationship at low and high frequencies, indicating that oscillations in cerebral blood flow velocity are influenced by steady-state cerebrovascular resistance and vascular compliance.
Cite This Study
Zhang et al. (2009) studied this question.