Population
Nine rabbits of either sex, 1.5-2.0 kg, from which the atrioventricular node was isolated and dissected into…
Comparison
Dissection into small specimens and application… vs Intact A-V node preparation before the…
Design
Preclinical
Authors
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Provides a simplified rabbit model for AV nodal automaticity research; leaves open translation to human conduction disorders.
Small specimens of rabbit A-V node exhibit spontaneous action potentials driven by slow inward currents and slow outward current kinetics, providing a useful model for studying A-V node automaticity.
Kokubun et al. (1980) studied this question.
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