Why the study?
LV myocardial dysfunction post-MI is linked to location, infarct size, and transmurality, but whether MI location differentially affects myocardial dysfunction using tissue-tracking needed evaluation.
Does infarct location independently affect left ventricular myocardial strain in patients with myocardial infarction?
Does infarct location independently affect left ventricular myocardial strain in patients with myocardial infarction?
Myocardial strain reduction after myocardial infarction is driven by infarct size and transmurality rather than the specific location of the infarction.
Post-MI strain reduction is independent of infarct location; leaves open dominant effects of size and transmurality in observational data.
Left ventricular (LV) myocardial dysfunction occurs after myocardial infarction (MI) is associated with the location, infarct size, and transmurality degrees of MI. The myocardial strain is a sensitive index used for the quantification of myocardium dysfunction. This study used Tissue-Tracking to evaluate whether the different location of MI would result in different myocardial dysfunction. One hundred patients diagnosed with MI who underwent cardiovascular magnetic resonance examination were included. The tissue-tracking indices, LV global radial strain (GRS), global circumferential strain (GCS), global longitudinal strain (GLS), and the infarct size (IS,% of LV mass) were quantified. There were 42 cases of anterior wall MI (AWMI) and 58 cases of non-anterior wall MI (NAWMI). The GCS of AWMI was significantly lower than that of NAWMI ( P = 0.036). In the same level of infarct size, the myocardial strain of AWMI was not significantly different from NAWMI group ( P > 0.05). The GRS and GCS were significantly different between transmurality > 50% group with transmurality ≤ 50% group ( P < 0.05). The present study demonstrated that LV MI is associated with reduced myocardial strain, and the infarct size and degrees of transmurality were both related to the decline of myocardial strain in patients with MI.
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Li et al. (2020) studied this question.
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