January 1, 2001Japanese Circulation Journal-english EditionOpen Access

Relationship Between Cardiac 123I-Metaiodobenzylguanidine Imaging and the Transcardiac Gradient of Neurohumoral Factors in Patients With Dilated Cardiomyopathy.

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Why the study?

Does the transcardiac gradient of neurohumoral factors correlate with cardiac 123I-MIBG imaging parameters in patients with dilated cardiomyopathy?

Population

42 consecutive patients with dilated cardiomyopathy and left ventricular dysfunction, mean age 56 years, 30…

Design

Cross-sectional

Authors

TMToshiki MatsuiKyoto University TTTakayoshi TsutamotoHeart Failure & Transplant MKMasahiko KinoshitaGoethe University Frankfurt

Discussion

Member takes

Implication

MIBG parameters associate with neurohumoral gradients in DCM; hypothesis-generating, prospective studies needed before clinical adoption.

Structured PICO

Does the transcardiac gradient of neurohumoral factors correlate with cardiac 123I-MIBG imaging parameters in patients with dilated cardiomyopathy?

Population

42 consecutive patients with dilated cardiomyopathy (DCM) and left ventricular dysfunction (LVEF ≤45%), mean age 56 years, 30 men and 12 women. Excluded: valvular disease, ischemic cardiomyopathy, chronic renal failure, diabetes mellitus, and autonomic nervous system disorder.

Intervention

Cardiac 123I-metaiodobenzylguanidine (MIBG) imaging and measurement of neurohumoral factors (norepinephrine and brain natriuretic peptide) in the aorta and coronary sinus via cardiac catheterization.

Outcome

Correlation between cardiac MIBG parameters (heart/mediastinum ratio and washout rate) and the transcardiac gradient of norepinephrine (NE) and brain natriuretic peptide (BNP).surrogate

In patients with dilated cardiomyopathy, the cardiac MIBG H/M ratio reflects the transcardiac gradient of BNP (indicating ventricular dysfunction), while the washout rate reflects the transcardiac gradient of norepinephrine (indicating altered sympathetic nerve terminals).

Limitations

Did not measure coronary sinus flow
Treatments varied among patients and the effects of medications on cardiac MIBG activity were not clarified
Did not assess the early H/M ratio

Cite This Study

Matsui et al. (2001) studied this question.

synapsesocial.com/papers/6a76369cb52b7ee7dcfbe7fb https://doi.org/10.1253/jcj.65.1041

Topics

Heart failure HFrEF treatment

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Relationship Between Cardiac 123I-Metaiodobenzylguanidine Imaging and the Transcardiac Gradient of Neurohumoral Factors in Patients With Dilated Cardiomyopathy.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Relationship Between Cardiac 123I-Metaiodobenzylguanidine Imaging and the Transcardiac Gradient of Neurohumoral Factors in Patients With Dilated Cardiomyopathy.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Topics

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