The excitatory action of adenosine on respiration is likely mediated by an A2 type of adenosine receptor based on the antagonist profile of various xanthines.
Animal data implicate A2 receptors in adenosine-driven respiratory excitation; leaves open human translation and clinical relevance.
The use of xanthines to characterize the adenosine receptor involved in excitation of respiration revealed that XCC, PD 115, 199 and XAC have much higher affinities than DPCPX followed by PACPX, DPX and 8-PT, which is compatible with an A2 type of adenosine receptor.
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Ribeiro et al. (1991) studied this question.
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